Electrophysiology – MCQs 50 Score: 0 Attempted: 0/50 Subscribe 1. The resting membrane potential of a typical mammalian neuron is approximately: (A) –40 mV (B) –55 mV (C) –70 mV (D) –90 mV 2. The Nernst equation is used to calculate: (A) Membrane resistance (B) Equilibrium potential for an ion (C) Threshold potential (D) Synaptic delay 3. Which ion is primarily responsible for depolarization during an action potential? (A) Potassium (K⁺) (B) Sodium (Na⁺) (C) Calcium (Ca²⁺) (D) Chloride (Cl⁻) 4. Repolarization of the action potential is mainly due to: (A) Influx of sodium (B) Efflux of potassium (C) Influx of calcium (D) Efflux of chloride 5. The Goldman-Hodgkin-Katz equation accounts for: (A) Single ion concentration (B) Multiple ion permeabilities (C) Only sodium channels (D) Resting potential in plants 6. Voltage-gated sodium channels are blocked by: (A) Tetrodotoxin (TTX) (B) Ouabain (C) Curare (D) Lidocaine 7. Which ion triggers neurotransmitter release at the synapse? (A) Na⁺ (B) K⁺ (C) Ca²⁺ (D) Cl⁻ 8. Patch-clamp technique is used to: (A) Measure single ion channel activity (B) Record brain imaging signals (C) Study protein folding (D) Detect neurotransmitters directly 9. The refractory period ensures that: (A) Action potentials travel in one direction (B) Neurons fire continuously (C) Membrane potential is always depolarized (D) Synapses do not release neurotransmitters 10. Myelination increases conduction velocity by: (A) Continuous conduction (B) Saltatory conduction (C) Increasing ion leakage (D) Removing refractory periods 11. Nodes of Ranvier are rich in: (A) Na⁺ channels (B) K⁺ channels only (C) Ca²⁺ pumps (D) Cl⁻ transporters 12. The synaptic delay is typically: (A) 0.01 ms (B) 0.1–0.5 ms (C) 1–2 ms (D) 10 ms 13. The Hodgkin-Huxley model describes: (A) Ion channel kinetics in squid axon (B) Synaptic plasticity (C) Glial cell functions (D) Muscle contraction 14. Which current dominates during the plateau phase of cardiac action potential? (A) Na⁺ influx (B) K⁺ efflux (C) Ca²⁺ influx (D) Cl⁻ influx 15. Which electrode technique measures extracellular potentials? (A) Intracellular sharp electrodes (B) Field potential recording (C) Patch-clamp whole-cell (D) Voltage clamp 16. The QRS complex in ECG represents: (A) Atrial depolarization (B) Ventricular depolarization (C) Atrial repolarization (D) Ventricular repolarization 17. The P wave in ECG corresponds to: (A) Atrial depolarization (B) Ventricular depolarization (C) Ventricular repolarization (D) SA node activity only 18. The T wave in ECG represents: (A) Atrial depolarization (B) Ventricular depolarization (C) Ventricular repolarization (D) SA node firing 19. The threshold potential in most neurons is around: (A) –90 mV (B) –70 mV (C) –55 mV (D) –30 mV 20. Inhibitory postsynaptic potentials (IPSPs) are often mediated by: (A) Na⁺ influx (B) K⁺ efflux or Cl⁻ influx (C) Ca²⁺ influx (D) ATP hydrolysis 21. Excitatory neurotransmitters typically cause: (A) Depolarization (B) Hyperpolarization (C) No change in membrane potential (D) DNA synthesis 22. Electroencephalography (EEG) measures: (A) Extracellular electrical activity of brain (B) Single ion channel currents (C) Action potentials in muscle (D) Cardiac potentials 23. Electromyography (EMG) records: (A) Brain activity (B) Skeletal muscle electrical activity (C) Cardiac activity (D) Synaptic vesicle release 24. Calcium-induced calcium release (CICR) is important in: (A) Neuronal transmission (B) Cardiac muscle contraction (C) Skeletal muscle relaxation (D) Nerve regeneration 25. The conduction velocity of unmyelinated axons is typically: (A) 0.1–1 m/s (B) 1–2 m/s (C) 10–20 m/s 26. Axonal conduction velocity increases with: (A) Increased diameter (B) Decreased diameter (C) Higher membrane resistance (D) Lower temperature 27. The end-plate potential (EPP) is generated at: (A) Neuromuscular junction (B) Axon hillock (C) Dendritic spine (D) Myelin sheath 28. The role of the sodium-potassium pump is to: (A) Maintain resting potential by pumping 3 Na⁺ out and 2 K⁺ in (B) Pump Na⁺ into cell (C) Pump K⁺ out only (D) Generate action potential directly 29. Which ion channel type is critical for pacemaker activity in the heart? (A) Funny (If) channels (B) Voltage-gated Na⁺ channels (C) Voltage-gated K⁺ channels (D) Ligand-gated Cl⁻ channels 30. Long-term potentiation (LTP) requires activation of: (A) NMDA receptors (B) GABA receptors (C) Glycine receptors (D) Nicotinic receptors 31. Which current is responsible for the afterhyperpolarization phase? (A) Na⁺ influx (B) K⁺ efflux (C) Ca²⁺ influx (D) Cl⁻ efflux 32. Voltage clamp technique allows: (A) Control of membrane potential to study ionic currents (B) Measurement of intracellular resistance only (C) Direct imaging of ion channels (D) Recording of synaptic vesicles 33. Which toxin blocks voltage-gated K⁺ channels? (A) Tetraethylammonium (TEA) (B) Tetrodotoxin (C) Curare (D) Bungarotoxin 34. In the heart, Purkinje fibers are specialized for: (A) Fast conduction of action potentials (B) Slow pacemaker activity (C) Synaptic integration (D) Neurotransmitter release 35. Action potentials are generated at the axon hillock because: (A) High density of voltage-gated Na⁺ channels (B) Low resistance (C) Large surface area (D) Presence of myelin 36. Local anesthetics block action potentials by: (A) Blocking voltage-gated Na⁺ channels (B) Blocking K⁺ leak channels (C) Blocking Ca²⁺ channels (D) Blocking ATP pumps 37. The refractory period prevents: (A) Backward propagation of action potentials (B) Saltatory conduction (C) Synaptic transmission (D) Myelin formation 38. The unit of conductance is: (A) Siemens (B) Ohm (C) Volt (D) Ampere 39. Electrical synapses transmit signals via: (A) Gap junctions (B) Chemical neurotransmitters (C) Voltage-gated Na⁺ channels (D) Ligand-gated K⁺ channels 40. Chemical synapses differ from electrical synapses by: (A) Presence of neurotransmitter release and synaptic delay (B) Bidirectional signaling (C) Zero delay transmission (D) Passive conduction 41. Ionotropic receptors mediate: (A) Fast synaptic transmission (B) Slow synaptic transmission (C) DNA replication (D) Action potential conduction in myelin 42. Metabotropic receptors act via: (A) G-proteins and second messengers (B) Direct ion channel opening (C) Gap junctions (D) Synaptic vesicle release 43. Electrooculography (EOG) records: (A) Eye movement-related electrical activity (B) Skeletal muscle activity (C) Heart potentials (D) Brain waves 44. Electroretinography (ERG) measures: (A) Retinal electrical responses to light (B) Corneal resistance (C) Optic nerve blood flow (D) Pupil constriction 45. Which current is responsible for neurotransmitter vesicle fusion? (A) Ca²⁺ influx through voltage-gated channels (B) Na⁺ influx (C) K⁺ efflux (D) Cl⁻ influx 46. Hyperpolarization occurs when: (A) Membrane potential becomes more negative than resting potential (B) Na⁺ channels open (C) K⁺ channels close (D) Threshold is crossed 47. Which current maintains the plateau in ventricular action potentials? (A) Slow inward Ca²⁺ current (B) Fast Na⁺ current (C) Delayed K⁺ current (D) Funny current 48. EPP at neuromuscular junction is caused by: (A) Acetylcholine binding to nicotinic receptors (B) Na⁺ influx via voltage-gated channels (C) ATP hydrolysis (D) K⁺ efflux 49. Electrocardiography (ECG) records: (A) Electrical activity of the heart (B) Skeletal muscle contraction (C) Brain waves (D) Synaptic potentials 50. The main role of electrophysiology in neuroscience is to: (A) Measure electrical properties of cells and tissues (B) Measure mechanical properties of tissues (C) Visualize macromolecules (D) Sequence nucleic acids Molecular Biophysics – MCQsCellular Biophysics – MCQsMembrane Biophysics – MCQsNeurobiophysics – MCQsRadiation Biophysics – MCQsMedical Biophysics – MCQsComputational Biophysics – MCQsStructural Biophysics – MCQsBiophysical Chemistry – MCQsBioenergetics – MCQsBiomechanics – MCQsSystems Biophysics – MCQsBiomolecular Interactions – MCQsBiophysical Methods & Instrumentation – MCQsQuantum Biophysics – MCQsThermodynamics & Statistical Mechanics in Biology – MCQsBiophysics of Macromolecules – MCQs Electrophysiology – MCQsPhotobiophysics – MCQsNanobiophysics – MCQs