Radiation Biophysics – MCQs 50 Score: 0 Attempted: 0/50 Subscribe 1. The unit of absorbed radiation dose is: (A) Sievert (B) Gray (C) Becquerel (D) Curie 2. The unit of equivalent radiation dose that accounts for biological effect is: (A) Gray (B) Sievert (C) Coulomb (D) Joule 3. The SI unit of radioactivity is: (A) Curie (B) Becquerel (C) Roentgen (D) Sievert 4. Ionizing radiation causes biological damage mainly by: (A) Protonation (B) DNA strand breaks (C) Osmotic imbalance (D) Protein folding 5. The most damaging type of DNA lesion from ionizing radiation is: (A) Single-strand break (B) Double-strand break (C) Base substitution (D) Deamination 6. Non-ionizing radiation includes: (A) Alpha particles (B) Gamma rays (C) Ultraviolet light (D) Beta particles 7. Gamma radiation is a type of: (A) Particle radiation (B) Electromagnetic radiation (C) Thermal radiation (D) Sound wave 8. Alpha particles have: (A) High penetration, low ionization (B) Low penetration, high ionization (C) High penetration, high ionization (D) Low penetration, low ionization 9. The linear energy transfer (LET) of alpha particles compared to gamma rays is: (A) Lower (B) Higher (C) Equal (D) Zero 10. The primary target of ionizing radiation in cells is: (A) Lipids (B) DNA (C) Carbohydrates (D) Enzymes 11. Stochastic effects of radiation include: (A) Skin burns (B) Cataracts (C) Cancer induction (D) Acute radiation syndrome 12. Deterministic effects of radiation are characterized by: (A) Probability without threshold (B) Severity increases with dose, threshold exists (C) No relation to dose (D) Occur randomly at low doses 13. The most radiosensitive phase of the cell cycle is: (A) G0 (B) G1 (C) S (D) M 14. Radiation-induced ionization of water produces: (A) O₂ molecules (B) Free radicals (C) ATP (D) Enzymes 15. Hydroxyl radicals generated by radiation are: (A) Protective (B) Highly reactive and damaging (C) Energy storage molecules (D) Neutral buffers 16. The oxygen enhancement ratio (OER) refers to: (A) Increased DNA repair in hypoxia (B) Increased radiation damage in presence of oxygen (C) Reduced effect of UV radiation (D) Enhanced energy metabolism 17. Radiosensitivity of cells follows which law? (A) Mendel’s law (B) Bergonie and Tribondeau law (C) Boyle’s law (D) Hardy-Weinberg law 18. Cells most sensitive to radiation are: (A) Differentiated neurons (B) Rapidly dividing cells (C) Muscle cells (D) Mature red blood cells 19. Acute radiation syndrome is caused by: (A) Low doses over years (B) High doses in short time (C) UV exposure (D) Microwave exposure 20. The prodromal stage of acute radiation syndrome includes: (A) Hair loss (B) Nausea, vomiting, fatigue (C) Organ failure (D) Skin ulceration 21. The lethal dose for 50% of humans within 30 days (LD50/30) is about: (A) 1 Gy (B) 4 Gy (C) 10 Gy (D) 20 Gy 22. The most penetrating type of radiation is: (A) Alpha (B) Beta (C) Gamma (D) Neutron 23. Neutrons are biologically damaging because they: (A) Produce secondary charged particles (B) Directly ionize DNA (C) Are electromagnetic (D) Carry high charge 24. Whole-body exposure to >10 Gy typically causes: (A) Hematopoietic syndrome (B) Gastrointestinal syndrome (C) Cerebrovascular syndrome (D) Skin erythema 25. The dose limit for occupational radiation workers is approximately: (A) 1 mSv/year (B) 20 mSv/year (C) 100 mSv/year (D) 1 Sv/year 26. The ALARA principle in radiation safety stands for: (A) As Low As Reasonably Achievable (B) Absolute Limit of Acceptable Radiation Amount (C) Applied Low Absorption Radiation Approach (D) Advanced Limiting And Reduction Agreement 27. Dosimeters are used to measure: (A) Temperature (B) Radiation exposure (C) Cell growth (D) Free radical levels 28. Thermoluminescent dosimeters (TLDs) work by: (A) Absorbing UV radiation (B) Trapping electrons in crystals (C) Storing energy in DNA (D) Using photomultipliers 29. Geiger-Müller counters are primarily used for detecting: (A) Neutrons only (B) Ionizing radiation particles and photons (C) Temperature gradients (D) Ultrasound waves 30. The Bragg peak is associated with: (A) Neutron beams (B) Proton therapy (C) Gamma radiation (D) Alpha particles in air 31. Radiation therapy aims to: (A) Increase mitosis in tumor cells (B) Kill cancer cells while sparing normal tissue (C) Reduce immune response (D) Enhance cell metabolism 32. Fractionation in radiotherapy is used to: (A) Deliver the entire dose at once (B) Spread dose over time to allow tissue repair (C) Reduce oxygen levels (D) Increase DNA repair in tumors 33. Radiosensitizers work by: (A) Protecting normal tissues (B) Increasing tumor sensitivity to radiation (C) Preventing DNA repair in normal cells (D) Blocking free radical formation 34. Radioprotectors such as amifostine function by: (A) Absorbing radiation directly (B) Scavenging free radicals (C) Increasing DNA replication (D) Blocking sodium channels 35. Radiation hormesis refers to: (A) Cancer induction by high doses (B) Possible beneficial effects of low doses (C) Complete DNA destruction (D) Increased oxygen toxicity 36. Non-stochastic effects of radiation are also called: (A) Probabilistic effects (B) Deterministic effects (C) Random effects (D) Cumulative effects 37. Cataract formation from radiation is classified as: (A) Stochastic effect (B) Deterministic effect (C) Probabilistic effect (D) Adaptive effect 38. The half-life of a radioactive isotope is defined as: (A) Time for 10% decay (B) Time for 25% decay (C) Time for 50% decay (D) Time for complete decay 39. Radioisotope iodine-131 is commonly used in treatment of: (A) Brain tumors (B) Thyroid disorders (C) Lung cancer (D) Liver disease 40. PET scans use radioisotopes that emit: (A) Alpha particles (B) Positrons (C) Neutrons (D) Gamma rays directly 41. Bremsstrahlung radiation is produced when: (A) Alpha particles collide (B) Electrons are decelerated near nuclei (C) Protons are accelerated (D) Gamma rays scatter 42. X-rays are generated when: (A) Electrons strike a metal target (B) Protons collide with neutrons (C) Nuclei undergo fission (D) DNA is ionized 43. Compton scattering involves: (A) Complete absorption of photons (B) Photon scattering off electrons (C) Proton emission (D) Neutron capture 44. Photoelectric effect in tissues is more significant at: (A) High photon energies (B) Low photon energies and high atomic number (C) Zero photon energies (D) Neutron irradiation 45. Radiation quality factor (QF) is used to: (A) Adjust dose for biological effectiveness (B) Measure radiation penetration (C) Detect isotopes (D) Calculate half-life 46. Which organ is most sensitive to radiation exposure? (A) Heart (B) Bone marrow (C) Kidney (D) Liver 47. The most common natural source of human radiation exposure is: (A) Cosmic rays (B) Radon gas (C) Food radiation (D) Nuclear fallout 48. The term “radiation weighting factor” is used in calculating: (A) Absorbed dose (B) Equivalent dose (C) Effective dose (D) Physical half-life 49. Radiation used in cancer imaging (CT scans) is primarily: (A) Gamma rays (B) X-rays (C) Alpha particles (D) Neutrons 50. 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